Search Clinical Resources

You are here:

Category - Articles by Topic

Chronic Pain
Additional Resources
Advances in managing chronic disease. Research, performance measurement, and quality improvement are key
Cannabinoids for treatment of chronic non-cancer pain; a systematic review of randomized trials
Cervico-thoracic or lumbar sympathectomy for neuropathic pain and complex regional pain syndrome (Review)
Complex regional pain syndrome: diagnosis and treatment
Diagnosis and Management of Neuropathic Pain: A Balanced Approach to Treatment
Management of chronic pain in older adults
Managing chronic pain in elderly patients requires a CHANGE of approach
Pharmacological Management of Persistent Pain in Older Persons
Prevalence and impact of pain among older adults in the United States: Findings from the 2011 National Health and Aging Trends Study
The Abbey pain scale: a 1-minute numerical indicator for people with end-stage dementia
The role of patient care teams in chronic disease management
Validation of proposed diagnostic criteria (the “Budapest Criteria”) for Complex Regional Pain Syndrome
Development and psychometric evaluation of the Pain Assessment in Advanced Dementia (PAINAD) scale.
Efficacy of treating pain to reduce behavioural disturbances in residents of nursing homes with dementia: cluster randomised clinical trial
Pain assessment for people with dementia: a systematic review of systematic reviews of pain assessment tools
Pain management in patients with dementia
Guideline for opioid therapy and chronic noncancer pain
Children's self-reports of pain intensity: scale selection, limitations and interpretation
Assessment tools for problematic opioid use in palliative care: A scoping review
The Role of Virtual Reality in Improving Health Outcomes for Community-Dwelling Older Adults: Systematic Review
The effectiveness, suitability, and sustainability of non-pharmacological methods of managing pain in community-dwelling older adults: a systematic review
Chronic Pain Management during the Covid-19 Pandemic: A Scoping Review
+ 20 Articles
Show all articles
Delirium
A multicomponent intervention to prevent delirium in hospitalized older patients.
Clarifying confusion: the confusion assessment method. A new method for detection of delirium
Delirium in elderly people.
Delirium in Hospitalized Older Adults.
Delirium in Older Persons: Advances in Diagnosis and Treatment
Detecting delirium among hospitalized older patients.
Interventions for preventing delirium in older people in institutional long-term care (Review)
Loud and Clear: Sensory Impairment, Delirium, and Functional Recovery in Critical Illness
Melatonin decreases delirium in elderly patients: A randomized, placebo-controlled trial
Prevention of delirium in hospitalized older patients: risk factors and targeted intervention strategies.
Promoting vision and hearing aids use in an intensive care unit
PHQ - 9 (The Patient Health Questionnaire)
Additional Resources
The delirium experience: what is the effect on patients, relatives and staff and what can be done to modify this?
6 Proven Strategies to Prevent Delirium in Older Adults
COVID-19: ICU delirium management during SARS-CoV-2 pandemic
Neural mechanisms of delirium: current hypotheses and evolving concepts
Neurologic Features in Severe SARS-CoV-2 Infection
Non-pharmacological interventions for preventing delirium in hospitalised non-ICU patients
Delirium pathophysiology - An updated hypothesis of the etiology of acute brain failure
Prevalence for delirium in stroke patients: A prospective controlled study
Echolalia
Delirium in acute stroke: a systematic review and meta-analysis
Cognitive Predictors of Delirium on Long-Term Follow-Up after TIA and Stroke: Population-Based Cohort Study
+ 21 Articles
Show all articles
Dementia
A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial
Depression and risk for Alzheimer Disease: Systematic Review, Meta-analysis, and Metaregression Analysis
Diagnosis, Classification and Natural History of Degenerative Dementias
Efficacy of Treating Pain to Reduce Behavioural Disturbances in Residents of Nursing Homes with Dementia - Cluster Randomized Clinical Trial
Forecasting the global burden of Alzheimer's disease.
Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria.
Hypomanic episode improved spontaneously after isolated acute cerebellar infarct: a case report.
Improving identification of cognitive impairment in primary care.
Management of mild to moderate Alzheimer’s disease and dementia.
Mid-life versus late-life depressive symptoms and risk of dementia: Differential effects for Alzheimer’s disease and vascular dementia
Mood disorders after stroke and their relation to lesion location. A CT scan study.
Persistent recurrence of hypomania and prosopoaffective agnosia in a patient with right thalamic infarct
Plasma homocysteine as a risk factor for dementia and Alzheimer's disease.
Position Statement of the American Association for Geriatric Psychiatry Regarding Principles of Care for Patients With Dementia Resulting From Alzheimer Disease
Predictors of the impact of nonpharmacologic interventions for agitation in nursing home residents with advanced dementia
Progression of subcortical ischemic disease from vascular depression to vascular dementia.
Progressively lowered stress threshold model - understanding behavioral symptoms of dementia
Provisional diagnostic criteria for depression of Alzheimer disease.
Quantifying the unmet needs of caregivers of people with dementia
Screening for mild cognitive impairment: If not now, when?
Secondary mania of vascular origin in elderly patients: a report of two clinical cases.
Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia
Signs and symptoms preceding the diagnosis of Alzheimer’s disease: a systematic scoping review of literature from 1937 to 2016
Summary of the evidence on modifiable risk factors for cognitive decline and dementia: A population-based perspective
The association between mood and anxiety disorders with vascular diseases and risk factors in a nationally-representative sample
The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease
When Dementia is in the House 
Which unmet needs contribute to behavior problems in persons with advanced dementia
‘Vitamin D and cognition in older adults’: updated international recommendations
Folate, Vitamin B6 and Vitamin B12 Intake and Mild Cognitive Impairment and Probable Dementia in the Women’s Health Initiative Memory Study
Vitamin D, Cognition and Alzheimer’s Disease: The Therapeutic Benefit is in the D-Tails
Vitamin B12 and Cognitive Function: An Evidence-Based Analysis
Vitamin D deficiency as a risk factor for dementia: a systematic review and metaanalysis
Canadian Consensus Conference on Diagnosis and Treatment of Dementia (CCCDTD)5: Guidelines for management of vascular cognitive impairment
CCCDTD5: Reducing the risk of later-life dementia. Evidence informing the Fifth Canadian Consensus Conference on the Diagnosis and Treatment of Dementia (CCCDTD-5)
Effect of Citalopram on Agitation in Alzheimer's Disease – The CitAD Randomized Controlled Trial
Dementia incidence continues to increase with age in the oldest old: the 90+ study
Frontotemporal dementia
Evaluation of Suspected Dementia
Recommendations of the 5th Canadian Consensus Conference on the diagnosis and treatment of dementia
Additional Resources
Which Risk Factors Causally Influence Dementia? A Systematic Review of Mendelian Randomization Studies
Environmental risk factors for dementia: a systematic review
Cognitive Reserve, Alzheimer's Neuropathology, and Risk of Dementia: A Systematic Review and Meta-Analysis
Combining modifiable risk factors and risk of dementia- a systematic review and meta-analysis
+ 42 Articles
Show all articles
Driving and Older Adult
Driving Status and Risk of Entry Into Long-Term Care in Older Adults.
A Novel Low-Cost Solution for Driving Assessment in Individuals with and without Disabilities
Additional Resources
Driving Cessation and Health Outcomes in Older Adults
Driving evaluation methods for able-bodied persons and individuals with lower extremity disabilities- a review of assessment modalities
Driving Status and Risk of Entry Into Long-Term Care in Older Adults
Driving with a neurodegenerative disorder: an overview of the current literature
Effect of memantine on the progression of driving impairment in mild Alzheimer's disease
How effective is the Trail Making Test (Parts A and B) in identifying cognitively impaired drivers?
Longitudinal decline of driving safety in Parkinson disease
Management of mild to moderate Alzheimer’s disease and dementia
Parkinson's Disease and Driving - Parkinson's Canada Form
Practice parameter update- evaluation and management of driving risk in dementia- report of the Quality Standards Subcommittee of the American Academy of Neurology
Systematic Review of Driving Risk and the Efficacy of Compensatory Strategies in Persons with Dementia
Update on the Risk of Motor Vehicle Collision or Driving Impairment with Dementia: A Collaborative International Systematic Review and Meta-Analysis
Cognitive Tests and Determining Fitness to Drive in Dementia: A Systematic Review
Shifting gears versus sudden stops: qualitative study of consultations about driving in patients with cognitive impairment
+ 14 Articles
Show all articles
Falls & Bone Health
A Public Health Approach to Fall Prevention among Older Persons in Canada
Additional Resources
Clinical Practice Guidelines for the assessment and prevention of falls in Older People
Effective Exercise for the Prevention of Falls: A Systematic Review and Meta-Analysis
Exercise to prevent falls in older adults: an updated meta-analysis and best practice recommendations
Falls & Related Injuries among Older Canadians: Fall-related Hospitalizations & Prevention Initiatives
Falls, Injuries due to Falls, and the Risk of Admission to a Nursing Home
Falls: Epidemiology, Pathophysiology, and Relationship to Fracture
Hip protectors for preventing hip fractures in older people (Review)
Interventions for preventing falls in older people in care facilities and hospitals (Review)
Predictors and prognosis of inability to get up after falls among elderly persons
Prospective Study of the Impact of Fear of Falling on Activities of Daily Living, SF-36 Scores, and Nursing Home Admission
Public Health Agency of Canada: Report on Seniors' falls in Canada (2005)
Public Health Agency of Canada: Seniors' Falls In Canada, 2nd Report
Recent opioid use and fall-related injury among older patients with trauma
Summary of the Updated American Geriatrics Society/British Geriatrics Society Clinical Practice Guideline for Prevention of Falls in Older Persons
The Patient Who Falls: “It’s Always a Trade-off”
The Timed "Up & Go": A Test of Basic Functional Mobility for Frail Elderly Persons
Video capture of the circumstances of falls in elderly people residing in long-term care: an observational study
What are the main risk factors for falls amongst older people and what are the most effective interventions to prevent these falls?
A Model of BMD Changes After Alendronate Discontinuation to Guide Postalendronate BMD Monitoring
BMD Changes and Predictors of Increased Bone Loss in Postmenopausal Women After a 5-Year Course of Alendronate
Effect of Bisphosphonate Use on Risk of Postmenopausal Breast Cancer: Results From the Randomized Clinical Trials of Alendronate and Zoledronic Acid
Effects of continuing or stopping alendronate after 5 years of treatment - the Fracture Intervention Trial Long-term Extension (FLEX) - a randomized trial
Efficacy of Continued Alendronate for Fractures in Women With and Without Prevalent Vertebral Fracture: The FLEX Trial
Flex Trial or Horizon Trial related to biphosphonates trial or holiday
Fracture Prediction After Discontinuation of 4 to 5 Years of Alendronate Therapy: The FLEX Study
Managing Osteoporosis Patients after Long-Term Bisphosphonate Treatment: Report of a Task Force of the American Society for Bone and Mineral Research
Mineralization Density Distribution of Postmenopausal Osteoporotic Bone Is Restored to Normal After Long-Term Alendronate Treatment: qBEI and sSAXS Data From the Fracture Intervention Trial Long-Term Extension (FLEX)
Randomized Trial of Effect of Alendronate Continuation Versus Discontinuation in Women With Low BMD: Results From the Fracture Intervention Trial Long-Term Extension
Mortality, Independence in Living, and Re-fracture, One Year Following Hip Fracture in Canadians
Recommendations for preventing fracture in long-term care
Strategies to overcome barriers to implementing osteoporosis and fracture prevention guidelines in long-term care: a qualitative analysis of action plans suggested by front line staff in Ontario, Canada
Successful knowledge translation intervention in long-term care: final results from the vitamin D and osteoporosis study (ViDOS) pilot cluster randomized controlled trial
Survival and functional outcomes after hip fracture among nursing home residents
The Cost of Injury in Canada - The clock is ticking...
+ 33 Articles
Show all articles
Frailty
A global clinical measure of fitness and frailty in elderly people
A simple frailty questionnaire (FRAIL) predicts outcomes in middle aged African Americans.
A standard procedure for creating a frailty index.
Association between frailty and delirium in older adult patients discharged from hospital
Frailty and the Prediction of Negative Health Outcomes: A Meta-Analysis.
Frailty in Older Adults: Evidence for a Phenotype
Prevalence and 10-Year Outcomes of Frailty in Older Adults in Relation to Deficit Accumulation
Risk factors for functional status decline in community-living elderly people: a systematic literature review.
The effectiveness of a comprehensive geriatric assessment intervention program for frailty in community-dwelling older people: a randomized, controlled trial.
The impact of frailty and delirium on mortality in older inpatients
Comprehensive Geriatric Assessment for community-dwelling, high-risk, frail, older people (Protocol)
Frailty in elderly people
Frailty in the critically ill: a novel concept
Additional Resources
Whey protein ingestion in elderly results in greater muscle protein accrual than ingestion of its constituent essential amino acid content
Prevalence of and interventions for sarcopenia in ageing adults: a systematic review. Report of the International Sarcopenia Initiative (EWGSOP and IWGS).
Clinical Frailty Scale
Risk factors for death in adult COVID-19 patients: Frailty predicts fatal outcome in older patients
Geriatric syndromes: clinical, research, and policy implications of a core geriatric concept
Health outcome prioritization to elicit preferences of older persons with multiple health conditions
Older age and frailty are the chief predictors of mortality in COVID-19 patients admitted to an acute medical unit in a secondary care setting- a cohort study
Association between anemia and frailty in 13,175 community-dwelling adults aged 50 years and older in China
Hemoglobin concentration is associated with self-reported disability and reduced physical performance in a community dwelling population of nonagenarians: the Mugello Study
Association Between Non-Iron-Deficient Anemia and Insomnia Symptoms in Community-Dwelling Older Adults: The Baltimore Longitudinal Study of Aging
+ 21 Articles
Show all articles
Incontinence
2012 Update: Guidelines for Adult Urinary Incontinence Collaborative Consensus Document for the Canadian Urological Association
Additional Resources
Appropriateness of oral drugs for long-term treatment of lower urinary tract symptoms in older persons: results of a systematic literature review and international consensus validation process (LUTS-FORTA 2014)
AUA White Paper on Nonneurogenic Chronic Urinary Retention: Consensus Definition, Treatment Algorithm, and Outcome End Points.
Development of a core set of outcome measures for OAB treatment
Diagnosis and treatment of overactive bladder (non-neurogenic) in adults: AUA/SUFU guideline.
Flexible-Dose Fesoterodine in Elderly Adults with Overactive Bladder: Results of the Randomized, Double-Blind, Placebo- Controlled Study of Fesoterodine in an Aging Population Trial
Persistence and adherence with the new beta-3 receptor agonist, mirabegron, versus antimuscarinics in overactive bladder: Early experience in Canada
The Association Between Anticholinergic Medication Burden and Health Related Outcomes in the ‘Oldest Old’
The efficacy and tolerability of the Beta 3-adrenoceptor agonist mirabegron for the treatment of symptoms of overactive bladder in older patients
The neural control of micturition
Urinary incontinence in frail elderly persons- Report from the 5th International Consultation on Incontinence
Use of Bladder Antimuscarinics in Older Adults with Impaired Cognition
Results after sacral nerve stimulation for chronic constipation.
American Geriatrics Society 2015 Updated Beers Criteria for Potentially Inappropriate Medication Use in Older Adults
Anticholinergic Drug Use and Risk to Cognitive Performance in Older Adults with Questionable Cognitive Impairment
Association of Anticholinergic Burden with Cognitive Impairment and Health Care Utilization Among a Diverse Ambulatory Older Adult Population
Bladder antimuscarinics and cognitive decline in elderly patients
Consensus validation of the FORTA (Fit fOR The Aged) List- a clinical tool for increasing the appropriateness of pharmacotherapy in the elderly
Cumulative use of strong anticholinergics and incident dementia- a prospective cohort study
How to Use the American Geriatrics Society 2015 Beers Criteria
+ 18 Articles
Show all articles
Mood Disorders
Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical Guidelines for the Management of Adults with Major Depressive Disorder: Section 3. Pharmacological Treatments
Comorbid anxiety disorders in late-life depression: results of a cohort study.
Comparison of diagnostic performance of Two-Question Screen and 15 depression screening instruments for older adults: Systematic review and meta-analysis
Depression among older adults: A 20 year update on give common myths and misconceptions
Depression and risk for Alzheimer Disease: Systematic Review, Meta-analysis, and Metaregression Analysis
Depression in the elderly
Depressive Disorders and Symptoms in Older Primary Care Patients: One Year Outcomes
Executive dysfunction and treatment response in late-life depression
Exercise for depression
Late life depression: a comparison of risk factors and symptoms according to age of onset in community dwelling older adults
Magnetic Resonance Imaging Predictors of Treatment Response in Late-Life Depression
Managing depression in older age: psychological interventions
Mid-life versus late-life depressive symptoms and risk of dementia: Differential effects for Alzheimer’s disease and vascular dementia
Phenomenology of depression in older compared with younger adults: meta-analysis.
Progression of subcortical ischemic disease from vascular depression to vascular dementia.
Provisional diagnostic criteria for depression of Alzheimer disease.
Risk factors for late-onset generalized anxiety disorder: results from a 12-year prospective cohort (the ESPRIT study).
The prognosis of depression in older patients in general practice and the community. A systematic review.
Age differences in the prevalence and co-morbidity of DSM-IV major depressive episodes: Results from the WHO World Mental Health Survey Initiative
Additional Resources
Sertraline and Mirtazapine Versus Placebo in Subgroups of Depression in Dementia: Findings From the HTA-SADD Randomized Controlled Trial
Impact of SSRI Therapy on Risk of Conversion From Mild Cognitive Impairment to Alzheimer’s Dementia in Individuals With Previous Depression
Music-based therapeutic interventions for people with dementia
Non-pharmacological Approaches to Depressed Elderly with No or Mild Cognitive Impairment in Long-Term Care Facilities. A Systematic Review of the Literature
The Effectiveness of Reminiscence Therapy on Alleviating Depressive Symptoms in Older Adults: A Systematic Review
+ 22 Articles
Show all articles
Movement Disorders
2015 Update on Parkinson disease
Additional Resources
Canadian Guidelines on Parkinson’s Disease
Double-Blind, Double-Dummy, Randomized Study of Continuous Intrajejunal Infusion of Levodopa-Carbidopa Intestinal Gel in Advanced Parkinson's Disease
Feeding Choices for People with Advanced Parkinson’s Disease
Mindfulness-based stress reduction in Parkinson’s disease: a systematic review
Parkinson’s disease dementia: a neural networks perspective
Parkinson’s disease: clinical features and diagnosis
Parkinson’s Disease: From Pathogenesis to Pharmacogenomics
Physical therapist interventions for Parkinson disease.
Progressive resistance training in Parkinson’s disease: a systematic review and meta-analysis
Systematic review on strength training in Parkinson’s disease: an unsolved question
The hallmarks of Parkinson’s disease
The Movement Disorder Society Evidence-Based Medicine Review Update: Treatments for the Non-Motor Symptoms of Parkinson's Disease
Treadmill training for patients with Parkinson’s disease (Review)
Treatment of Cognitive, Psychiatric, and Affective Disorders Associated with Parkinson’s Disease
Collective physician perspectives on non-oral medication approaches for the management of clinically relevant unresolved issues in Parkinson's disease
Practice guideline update summary- Botulinum neurotoxin for the treatment of blepharospasm, cervical dystonia, adult spasticity, and headache
Parkinson’s disease in the older patient
+ 16 Articles
Show all articles
Responsive Behaviours
Additional Resources
Assessment and management of behavioral and psychological symptoms of dementia
Effect of Citalopram on Agitation in Alzheimer's Disease – The CitAD Randomized Controlled Trial
Efficacy of nonpharmacologic interventions for agitation in advanced dementia: a randomized, placebo-controlled trial.
Predictors of the impact of nonpharmacologic interventions for agitation in nursing home residents with advanced dementia.
Progressively Lowered Stress Threshold Model: Understanding Behavioral Symptoms of Dementia
Quantifying the unmet needs of caregivers of people with dementia: a critical review of the quality of measures
Which unmet needs contribute to behavior problems in persons with advanced dementia?
Escitalopram versus risperidone for the treatment of behavioral and psychotic symptoms associated with Alzheimer's disease: a randomized double-blind pilot study.
Reduction of the Anticholinergic Burden Makes It Possible to Decrease Behavioral and Psychological Symptoms of Dementia.
Efficacy of treating pain to reduce behavioural disturbances in residents of nursing homes with dementia: cluster randomised clinical trial
Acupuncture for Behavioral and Psychological Symptoms of Dementia: A Systematic Review and Meta-Analysis
Acupuncture for Mild Cognitive Impairment and Dementia: An Overview of Systematic Reviews
Effectiveness and Safety of Aromatherapy in Managing Behavioral and Psychological Symptoms of Dementia: A Mixed-Methods Systematic Review
Herbal Medicine for Behavioral and Psychological Symptoms of Dementia: A Systematic Review and Meta-Analysis
+ 12 Articles
Show all articles
Sleep Disorders
Can sleep quality and wellbeing be improved by changing the indoor lighting in the homes of healthy, elderly citizens?
Narcolepsy - Review Article
Pharmacotherapies for sleep disturbances in dementia (Review)
Age-related changes of circadian rhythms and sleep-wake cycles
Association between difficulty initiating sleep in older adults and the combination of leisure-time physical activity and consumption of milk and milk products: a cross-sectional study.
Effectiveness of melatonin treatment on circadian rhythm disturbances in dementia
Effects of Diet on Sleep Quality
Insights into REM Sleep Behavior Disorder Pathophysiology in Brainstem-Predominant Lewy Body Disease
Melatonin decreases delirium in elderly patients- a randomized placebo-controlled trial
Music for insomnia in adults
Sleep Pathologies in Depression and the Clinical Utility of Polysomnography
Sleep Problems in the Elderly
Winter is coming- nightmares and sleep problems during seasonal affective disorder
Additional Resources
Treatment of sleep disorders in dementia
Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle
Cognitive Behavioral Therapy for Insomnia in Older Veterans Using Nonclinician Sleep Coaches: Randomized Controlled Trial
Dismantling multicomponent behavioral treatment for insomnia in older adults: a randomized controlled trial
Duration and quality of sleep among Canadians aged 18 to 79
Efficacy of brief behavioral treatment for chronic insomnia in older adults
Insomnia (primary) in older people
Insomnia in the Elderly: A Review
Optimizing sleep in older adults: treating insomnia
The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial
Sensory Stimulation for Nursing-Home Residents: Systematic Review and Meta-Analysis of Its Effects on Sleep Quality and Rest-Activity Rhythm in Dementia
Sleep Duration and Sleep Quality in Caregivers of Patients With Dementia: A Systematic Review and Meta-analysis
Sleep Quality and Aging: A Systematic Review on Healthy Older People, Mild Cognitive Impairment and Alzheimer's Disease
+ 24 Articles
Show all articles
Acute Changes
Articles coming soon
Elder Abuse
Articles coming soon