The neprilysin pathway in heart failure: a review and guide on the use of sacubitril/valsartan
Sorry, but you do not have permission to view this content.
Search Knowledge Base by Keyword
-
-
- A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial
- Comparison of cognitive and neuropsychiatric profiles in hospitalised elderly medical patients with delirium, dementia and comorbid delirium-dementia
- COVID-19 severity and age increase the odds of delirium in hospitalized adults with confirmed SARS-CoV-2 infection: a cohort study
- COVID-19-challenges for dementia care and research
- Dealing with Racist Patients
- Diagnosis, Classification and Natural History of Degenerative Dementias
- Escitalopram versus risperidone for the treatment of behavioral and psychotic symptoms associated with Alzheimer's disease: a randomized double-blind pilot study.
- Folate, Vitamin B6 and Vitamin B12 Intake and Mild Cognitive Impairment and Probable Dementia in the Women’s Health Initiative Memory Study
- Forecasting the global burden of Alzheimer's disease.
- Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria.
- Geriatric psychiatry review: differential diagnosis and treatment of the 3 D's - delirium, dementia, and depression
- Improving identification of cognitive impairment in primary care
- Persistent recurrence of hypomania and prosopoaffective agnosia in a patient with right thalamic infarct.
- Plasma homocysteine as a risk factor for dementia and Alzheimer's disease.
- Prevalence and Incidence Studies of Schizophrenic Disorders - A Systematic Review of the Literature
- Prevalence and risk factors for delirium in critically ill patients with COVID-19 (COVID-D): a multicentre cohort study
- Protocol for the development of versions of the Montreal Cognitive Assessment (MoCA) for people with hearing or vision impairment
- Racism Reported by Direct Care Workers in Long-Term Care Settings
- Recommendations on screening for cognitive impairment in older adults
- Screening for mild cognitive impairment: If not now, when?
- Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia.
- Summary of the evidence on modifiable risk factors for cognitive decline and dementia: A population-based perspective
- The assessment of cognition in visually impaired older adults
- The association between mood and anxiety disorders with vascular diseases and risk factors in a nationally-representative sample
- The Caregiver Burden of Delirium in Older Adults With Alzheimer Disease and Related Disorders
- The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging- Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease
- The GPCOG: a new screening test for dementia designed for general practice.
- Show all articles ( 12 ) Collapse Articles
-
- Additional Resources:
- An international road map to improve pain assessment in people with impaired cognition: the development of the Pain Assessment in Impaired Cognition (PAIC) meta-tool.
- Antipsychotic discontinuation after the initiation of selective serotonin reuptake inhibitors therapy for the treatment of behavioral and psychological symptoms associated with dementia
- Cannabinoids for the Neuropsychiatric Symptoms of Dementia: A Systematic Review and Meta-Analysis
- Delirium in Older People with COVID-19- Clinical Scenario and Literature Review
- Development and Psychometric Evaluation of the Pain Assessment in Advanced Dementia (PAINAD) Scale
- Difficult Resident or Personality Disorder? A Long-Term Care Perspective
- Efficacy of nonpharmacologic interventions for agitation in advanced dementia: a randomized, placebo-controlled trial.
- Efficacy of treating pain to reduce behavioural disturbances in residents of nursing homes with dementia: cluster randomised clinical trial
- Identifying and Managing Pain in People with Alzheimer’s Disease and Other Types of Dementia: A Systematic Review
- Intramuscular Olanzapine in the Management of Behavioral and Psychological Symptoms in Hospitalized Older Adults- A Retrospective Descriptive Study
- Management of the behavioral and psychological symptoms of dementia
- Position Statement of the American Association for Geriatric Psychiatry Regarding Principles of Care for Patients With Dementia Resulting From Alzheimer Disease
- Predictors of the impact of nonpharmacologic interventions for agitation in nursing home residents with advanced dementia.
- Progressively Lowered Stress Threshold Model: Understanding Behavioral Symptoms of Dementia
- Quantifying the unmet needs of caregivers of people with dementia: a critical review of the quality of measures
- Sexual disinhibition and dementia
- Simulated presence therapy for dementia (Review)
- Systematic review of systematic reviews of non-pharmacological interventions to treat behavioural disturbances in older patients with dementia. The SENATOR-OnTop series.
- The MOBID-2 pain scale: Reliability and responsiveness to pain in patients with dementia
- Which unmet needs contribute to behavior problems in persons with advanced dementia?
- Show all articles ( 6 ) Collapse Articles
-
- A systematic review of electrical stimulation for pressure ulcer prevention and treatment in people with spinal cord injuries
- Additional Resources
- Developing a Wound Care Program in Long-term Care: Changing the Focus from Products to Prevention
- Development and Implementation of a Hospital-Acquired Pressure Ulcer Incidence Tracking System and Algorithm
- Dressings and topical agents for arterial leg ulcers (Review)
- Dressings for treating foot ulcers in people with diabetes: an overview of systematic reviews (Review)
- Electrical Stimulation for Pressure Injuries: A Health Technology Assessment.
- Electromagnetic therapy for treating pressure ulcers.
- Foam dressings for healing diabetic foot ulcers (Review)
- How We Decreased the Costs of Wound Care Supplies at a Hospital and Long‑term‑care Home
- Hydrogel dressings for healing diabetic foot ulcers (Review)
- Mobile Devices as Adjunctive Pain Management Tools
- Negative pressure wound therapy for treating pressure ulcers (Review)
- Phototherapy for treating pressure ulcers (Review)
- Protease-modulating matrix treatments for healing venous leg ulcers (Review)
- Repeated use of immersive virtual reality therapy to control pain during wound dressing changes in pediatric and adult burn patients
- The Impact of Virtual Reality on Chronic Pain
- The venous ulcer continues to be a clinical challenge: an update
- Topical silver for treating infected wounds (Review)
- Use of virtual reality for treating burned children: case reports
- Show all articles ( 5 ) Collapse Articles
-
- ‘Practical’ resources to support patient and family engagement in healthcare decisions: a scoping review
- A Systematic Review of Family Meeting Tools in Palliative and Intensive Care Settings
- Additional Resources
- ARC Family Check-in for Engaging Families
- Getting more health from healthcare: quality improvement must acknowledge patient coproduction
- Innovation Implementation in the Context of Hospital QI: Lessons Learned and Strategies for Success
- SBAR Worksheet - Engaging Families
-
- 2010 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada: summary
- A Pooled Analysis of Vitamin D Dose Requirements for Fracture Prevention
- Additional Resources
- An interdisciplinary knowledge translation intervention in long-term care- Study protocol for the vitamin D and osteoporosis study (ViDOS) pilot cluster randomized controlled trial
- Comparative Effectiveness of Drug Treatments to Prevent Fragility Fractures- A Systematic Review and Network Meta-Analysis
- Comparative trends in incident fracture rates for all long-term care and community-dwelling seniors in Ontario, Canada, 2002-2012.
- Direct health-care costs attributed to hip fractures among seniors: a matched cohort study
- Fracture Risk Scale (FRS) Added to MDS 2.0 Assessments
- Freezing of gait and fall detection in Parkinson’s disease using wearable sensors: a systematic review
- Hip Fractures in Long-Term Care: Is the Excess Explained by the Age and Gender Distribution of the Residents?
- Hospitalization Rates of Nursing Home Residents and Community-Dwelling Seniors in British Columbia
- Postmenopausal Osteoporosis
- Quality of Care and Mortality among Long-term Care Residents with Dementia
- Recommendations for preventing fracture in long-term care
- Relationship between regulatory status, quality of care, and three-year mortality in Canadian residential care facilities- a longitudinal study
- Risk of subsequent fracture after prior fracture among older women
- Risk of subsequent fracture and mortality within 5 years after a non-vertebral fracture
- Survey on Fall Detection and Fall Prevention Using Wearable and External Sensors
- Survival and functional outcomes after hip fracture among nursing home residents
- The current economic burden of illness of osteoporosis in Canada
- The Effect of Fall Biomechanics on Risk for Hip Fracture in Older Adults- A Cohort Study of Video-Captured Falls in Long-Term Care
- Type and Location of Wearable Sensors for Monitoring Falls during Static and Dynamic Tasks in Healthy Elderly- A Review
- Video capture of the circumstances of falls in elderly people residing in long-term care- an observational study
- Warning of an increased risk of vertebral fracture after stopping denosumab
- Show all articles ( 9 ) Collapse Articles
-
- Collective physician perspectives on non-oral medication approaches for the management of clinically relevant unresolved issues in Parkinson's disease
- Feeding Choices for People with Advanced Parkinson’s Disease
- Levodopa: 50 years of a revolutionary drug for Parkinson disease.
- MDS Clinical Diagnostic Criteria for Parkinson’s Disease
- Parkinson’s disease dementia: a neural networks perspective
- Pharmacological treatment of Parkinson disease: a review.
- Prevalence of pain in Parkinson's disease: a systematic review using the modified QUADAS tool.
- Progressive resistance training in Parkinson’s disease: a systematic review and meta-analysis
- Subthalamic neurostimulation for Parkinson's disease with early fluctuations: balancing the risks and benefits.
- Systematic review on strength training in Parkinson’s disease: an unsolved question
- The hallmarks of Parkinson’s disease
- Treatment of Cognitive, Psychiatric, and Affective Disorders Associated with Parkinson’s Disease
-
- Additional Resources
- Ageing Is Associated with Decreases in Appetite and Energy Intake—A Meta-Analysis in Healthy Adults
- An Approach to the Nonpharmacologic and Pharmacologic Management of Unintentional Weight Loss Among Older Adults
- Anorexia of ageing: a key component in the pathogenesis of both sarcopenia and cachexia
- Mechanisms of the anorexia of aging—a review
- Mixed methods developmental evaluation of the CHOICE program: a relationship-centred mealtime intervention for long-term care
- Nutrition in Disguise: Development, Testing and Cost - Analysis of Nutrient-Enhanced Food for Residential Care.
- Prevalence of inadequate micronutrient intakes of Canadian long-term care residents
- Qualitative analysis of a virtual research meeting summarises expert-based strategies to promote hydration in residential care during COVID-19 and beyond.
- Short Sleep Duration and Dietary Intake: Epidemiologic Evidence, Mechanisms, and Health Implications
- Unintentional Weight Loss in Older Adults
- Whey protein ingestion in elderly results in greater muscle protein accrual than ingestion of its constituent essential amino acid content
-
- Association between sleep, childhood trauma and psychosis-like experiences
- Associations Between Trauma, Sleep, and Cognitive Impairment Among Latino and Asian Older Adults
- Comparison of Sleep Patterns in Vietnam Veterans With and Without Posttraumatic Stress Disorder Using Wrist Actigraphy
- Effectiveness of multicomponent nonpharmacological delirium interventions: a meta-analysis
- Sleep disturbances among older adults following traumatic brain injury
- The Nature of Trauma Pain and Its Association with Catastrophizing and Sleep
- The Relationship Between Childhood Trauma and Poor Sleep Health in Adulthood
- Trauma-Associated Sleep Disorder - A Post-traumatic Stress-REM Sleep Behavior Disorder Mash-Up
- Trauma-Informed Hospice and Palliative Care
-
- Additional Resources
- Barriers to palliative care for advanced dementia: a scoping review
- Comparison of Early Versus Late Palliative Care Consultation in End-of-Life Care for the Hospitalized Frail Elderly Patients
- Depression and anxiety in patients with COPD
- Efficacy of extended release quetiapine fumarate monotherapy in elderly patients with major depressive disorder: secondary analyses in subgroups of patients according to baseline anxiety, sleep disturbance, and pain levels
- Guiding a Goals of Care Discussion
-
- A prospective study of hepatic safety of statins used in very elderly patients
- Angiotensin–Neprilysin Inhibition versus Enalapril in Heart Failure
- Canadian Cardiovascular Society consensus conference recommendations on heart failure 2006: Diagnosis and management
- Cardiovascular Safety of β3-adrenoceptor Agonists for the Treatment of Patients with Overactive Bladder Syndrome
- Circadian variation of variability and irregularity of heart rate in patients with permanent atrial fibrillation
- Effect of Metoprolol Succinate in Patients with Stable Angina and Elevated Heart Rate Receiving Low-Dose β-Blocker Therapy
- Geriatric Medicine Leadership of Health Care Transformation: To Be or Not To Be?
- Interpretation of the evidence for the efficacy and safety of statin therapy
- Nebivolol versus Carvedilol or Metoprolol in Patients Presenting with Acute Myocardial Infarction Complicated by Left Ventricular Dysfunction
- Predictors of first-year nonadherence and discontinuation of statins among older adults- a retrospective cohort study
- Spironolactone for Heart Failure with Preserved Ejection Fraction
- Statins in the Prevention and Treatment of Heart Failure- a Review of the Evidence
- The Effect of Spironolactone on Exercise Tolerance and Arterial Function in Older Patients with HEpEF
- The first-in-man randomized trial of a beta3 adrenoceptor agonist in chronic heart failure: the BEAT-HF trial.
- The neprilysin pathway in heart failure: a review and guide on the use of sacubitril/valsartan
- The Prognostic Importance of Impaired Systolic Function in Heart Failure with Preserved Ejection Fraction and the Impact of Spironolactone
- The Value of Admission Clinical Data for Diagnosing Heart Failure in Long-term Care
- Show all articles ( 2 ) Collapse Articles
-
- Additional Resources
- Adverse drug reactions in elderly- challenges in identification and improving preventative strategies
- American Geriatrics Society Updated Beers Criteria for Potentially Inappropriate Medication Use in Older Adults
- Deciding when to stop: towards evidence-based deprescribing of drugs in older populations
- Deprescribing antipsychotics for behavioural and psychological symptoms of dementia and insomnia: Evidence-based clinical practice guideline
- Deprescribing Is an Essential Part of Good Prescribing
- Feasibility Study of a Systematic Approach for Discontinuation of Multiple Medications in Older Adults
- Individualizing prevention for older adults
- Interventions that can Reduce Inappropriate Prescribing in the Elderly - A Systematic Review
- Polypharmacy in the elderly: a fait accompli?
- Polypharmacy: Evaluating Risks and Deprescribing
- Reducing the Risk of Adverse Drug Events in Older Adults
- STOPP (Screening Tool of Older Persons’ potentially inappropriate Prescriptions): application to acutely ill elderly patients and comparison with Beers’ criteria
- The war against polypharmacy: a new cost effective geriatric-palliative approach for improving drug therapy in disabled elderly people
-
- Additional Resources
- Advances in managing chronic disease. Research, performance measurement, and quality improvement are key
- Assessment tools for problematic opioid use in palliative care: A scoping review
- Cannabinoids for treatment of chronic non-cancer pain; a systematic review of randomized trials
- Cervico-thoracic or lumbar sympathectomy for neuropathic pain and complex regional pain syndrome (Review)
- Children's self-reports of pain intensity: scale selection, limitations and interpretation
- Complex regional pain syndrome: diagnosis and treatment
- Development and psychometric evaluation of the Pain Assessment in Advanced Dementia (PAINAD) scale.
- Diagnosis and Management of Neuropathic Pain: A Balanced Approach to Treatment
- Efficacy of treating pain to reduce behavioural disturbances in residents of nursing homes with dementia: cluster randomised clinical trial
- Guideline for opioid therapy and chronic noncancer pain
- Management of chronic pain in older adults
- Managing chronic pain in elderly patients requires a CHANGE of approach
- Pain assessment for people with dementia: a systematic review of systematic reviews of pain assessment tools
- Pain management in patients with dementia
- Pharmacological Management of Persistent Pain in Older Persons
- Prevalence and impact of pain among older adults in the United States: Findings from the 2011 National Health and Aging Trends Study
- The Abbey pain scale: a 1-minute numerical indicator for people with end-stage dementia
- The McGill Pain Questionnaire
- The role of patient care teams in chronic disease management
- UHN Toronto Rehabilitation Institute - Patient Follow-Up Instructions Comprehensive Integrated Pain Program
- Validation of proposed diagnostic criteria (the “Budapest Criteria”) for Complex Regional Pain Syndrome
- Virtual Reality as a Distraction Technique in Chronic Pain Patients
- Show all articles ( 8 ) Collapse Articles
-
- A report on older-age bipolar disorder from the International Society for Bipolar Disorders Task Force
- A tune in "a minor" can "b major": a review of epidemiology, illness course, and public health implications of subthreshold depression in older adults
- Association of depression and gender with mortality in old age. Results from the Amsterdam Study of the Elderly (AMSTEL)
- Canadian Guidelines on Prevention, Assessment and Treatment of Depression Among Older Adults
- Cognitive functioning and late-life depression
- Definitions and factors associated with subthreshold depressive conditions: a systematic review
- Depression among older adults with diabetes mellitus
- Depression and anxiety in patients with COPD
- Diagnosing and Treating Depression in Patients with Alzheimer's Disease
- Late-life depression among black and white elderly homecare patients
- Loneliness among older adults in the community during COVID-19: a cross-sectional survey in Canada
- Post-Stroke Depression: A Review
- The association between loneliness and depressive symptoms among adults aged 50 years and older: a 12-year population-based cohort study
- The pathobiology of vascular dementia
-
- A better place to live, a better place to work- Ontario’s long-term care staffing plan 2020
- Additional Resources
- Assembling the Pieces - An Implementation Guide to the National Standard for Psychological Health and Safety in the Workplace
- Characteristics and Work Life Quality of Nursing Home Care Aides in Canada
- Nursing Home Employee and Resident Satisfaction and Resident Care Outcomes
- Ontario Long-Term Care Staffing Study 2020
- Re-imagining Long-term Residential Care in the COVID-19 Crisis
- The Association between the Perceived Adequacy of Workplace Infection Control Procedures and Personal Protective Equipment with Mental Health Symptoms: A Cross-sectional Survey of Canadian Health-care Workers during the COVID-19 Pandemic
- The ROI in workplace mental health programs
- Work and Wellbeing Survey Results - RNAO 2021
- Workplace Mental Health Priorities - Mental Health and Well-Being
-
-
-
- Session 01: Engaging Families in Care
- Session 02: Dementia - Screening, Assessment and Diagnosis
- Session 03: Behavioural and Psychological Symptoms of Dementia (BPSD)
- Session 04: Depression and Delirium
- Session 05: Congestive Heart Failure
- Session 06: Pressure Injuries
- Session 07: Palliative Care
- Session 08: Movement Disorders
- Session 09: Polypharmacy
- Session 10: Acute Changes
- Session 11: Sleep Disorders
- Session 12: Falls and Bone Health
-
- Session 01 - Responsive Behaviours
- Session 02 - Pressure Injuries
- Session 03 - Acute Changes
- Session 04 - Dementia
- Session 05 - Congestive Heart Failure
- Session 06 - Palliative Care/End of Life
- Session 07 - Fracture Prevention
- Session 08 - Engaging Families
- Session 09 - Movement Disorders
- Session 10 - Polypharmacy
-
- Session 01: Dementia
- Session 02: Responsive Behaviours
- Session 03: Preventing Acute Changes
- Session 04: Engaging Families in Care
- Session 05: Pressure Injuries
- Session 06: Fracture Prevention
- Session 07: Movement Disorders
- Session 08: Nutrition & Weight Loss
- Session 09: Polypharmacy
- Session 10: Sleep Disorders
- Session 11: Palliative Care
- Session 12: Heart Failure
-
- Session 1: Engaging Families in Care
- Session 10: Depression
- Session 11: Falls and Bone Health
- Session 12: Sleep Disorders
- Session 13: Movement Disorders
- Session 14: Delirium
- Session 2: Dementia
- Session 3: Responsive Behaviours
- Session 4: Pain
- Session 5: Workplace Mental Health
- Session 6: Diet and Nutrition
- Session 7: Palliative Care
- Session 8: Polypharmacy
- Session 9: Sexuality and Aging
-