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Additional Resources: Medical Cannabis in the Older Adult

UpToDate: Prazosin for sleep disturbance in PTSD (March 2018)

Six randomized clinical trials support the efficacy of prazosin for reducing sleep disturbance and nightmares in posttraumatic stress disorder (PTSD); participants were mostly military personnel or veterans. However, a new randomized trial, also in veterans with PTSD in greater number than in the other trials combined, failed to show benefits from prazosin [3]. Based on our clinical experience, we continue to suggest prazosin for PTSD-associated sleep disruption or nightmares, either as monotherapy or in conjunction with a selective serotonin reuptake inhibitor or a serotonin-norepinephrine reuptake inhibitor for other PTSD symptoms. Further research is needed to investigate whether subgroups of this population are uniquely responsive to prazosin.

Additional References:

Greer GR, Grob CS, Halberstadt AL. PTSD symptom reports of patients evaluated for the New Mexico Medical Cannabis Program. J Psychoactive Drugs. 2014 Jan-Mar;46(1):73-7.

Di Marzo V1, Bifulco M, De Petrocellis L. The endocannabinoid system and its therapeutic exploitation. Nat Rev Drug Discov. 2004 Sep;3(9):771-84. –

Online Resources:

Information for Health Care Professionals : Cannabis and the cannabinoids –

Simplified Cannabinoid Prescribing Guide – On-Line Supplement –

Medical Cannabinoids: Guideline Summary –

Patient Information: