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Additional Resources: Medical Cannabis in the Older Adult
UpToDate: Prazosin for sleep disturbance in PTSD (March 2018)
Six randomized clinical trials support the efficacy of prazosin for reducing sleep disturbance and nightmares in posttraumatic stress disorder (PTSD); participants were mostly military personnel or veterans. However, a new randomized trial, also in veterans with PTSD in greater number than in the other trials combined, failed to show benefits from prazosin . Based on our clinical experience, we continue to suggest prazosin for PTSD-associated sleep disruption or nightmares, either as monotherapy or in conjunction with a selective serotonin reuptake inhibitor or a serotonin-norepinephrine reuptake inhibitor for other PTSD symptoms. Further research is needed to investigate whether subgroups of this population are uniquely responsive to prazosin.
Greer GR, Grob CS, Halberstadt AL. PTSD symptom reports of patients evaluated for the New Mexico Medical Cannabis Program. J Psychoactive Drugs. 2014 Jan-Mar;46(1):73-7.
Di Marzo V1, Bifulco M, De Petrocellis L. The endocannabinoid system and its therapeutic exploitation. Nat Rev Drug Discov. 2004 Sep;3(9):771-84. – http://www.nature.com/articles/nrd1495
Information for Health Care Professionals : Cannabis and the cannabinoids – https://www.canada.ca/en/health-canada/services/drugs-medication/cannabis/information-medical-practitioners/information-health-care-professionals-cannabis-cannabinoids.html
Simplified Cannabinoid Prescribing Guide – On-Line Supplement – http://www.cfp.ca/content/cfp/suppl/2018/02/13/64.2.111.DC1/Cannabinoid_Guidelines_Supplment.pdf
Medical Cannabinoids: Guideline Summary – http://www.cfp.ca/content/cfp/suppl/2018/02/13/64.2.111.DC1/Cannabinoid_Guidelines_One-Pager.pdf